The West Coast Main Line connects the major cities of London, Birmingham, Manchester, Liverpool, Glasgow, and Edinburgh. The central core between London Euston and Glasgow Central covers 399 miles (642 km). As well as being a major InterCity route with many branches and divergences, it carries nearly half of all rail freight in the United Kingdom. The route was electrified in sections between 1955 and 1974, and is currently classed as a high speed line.
- WCML North - Developed by Krossrails and set in the mid-1990s from Glasgow Central to Carlisle.
- WCML Over Shap - Also developed by Krossrails, this route runs from Carlisle to Preston in the BR blue period of the 1970s.
- WCML London & the Midlands - A freeware route created by David J Scott (photons66) and released on UKTrainSim set in the modern day between London Euston and Birmingham New Street.